International Journal of Coronaviruses

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International Journal of Coronaviruses · ISSN 2692-1537

Current Issue

Volume 5, Issue 1 · Pages 1-30

The most recent issue of the journal on record. Each item below carries its authors and their institutions, the pages it occupies, the dates it was submitted, accepted and published, its license, and its DOI where one is registered.

Volume 5, Issue 1Current issue
4Items, of which 3 research articles
1-30Pages, continuous
18Authors
11With a verified ORCID iD

Contents

In this issue

Research

Research articles in this issue

Abstracts are the authors' own published text, reproduced without alteration, and each is dated. Work on SARS-CoV-2 published in 2023-2024 describes the state of knowledge at the time it was written.

Research article Pages 1-9

Comparative Analysis of Five Commercial RT-PCR Diagnostic Assay for Detection of Covid-19

Sepideh Hasanzadeh1,2  ORCID 0000-0001-6287-0800 · Ali Mehri3 · Saeedeh Hajebi Khaniki4  ORCID 0000-0001-7041-3802 · Behnam Azari5  ORCID 0000-0001-6612-1209 · Mahbubeh Jangi1 · Kiarash Ghazvivni1,6 · Saeid Amel Jamehdar1,6Corresponding  ORCID 0000-0003-4813-6399

  • 1Antimicrobial Resistance Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
  • 2Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
  • 3Endoscopic and Minimally Invasive Surgery research center, Mashhad University of Medical Sciences, Mashhad, Iran
  • 4Student Research Committee, Department of biostatics, school of health, Mashhad University of Medical Sciences, Iran
  • 5Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  • 6Depa rtment of Microbiology and virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract, as published 8 September 2023

SARS-CoV-2 real-time reverse-transcription PCR (rRT-PCR) is the most effective testing system available to combat COVID-19, given the absence of any specific treatment or vaccine. Moreover, numerous SARS-CoV-2 rRT-PCR kits have been approved under emergency-use-authorization (EUA) worldwide. In this article, we present a comparison of important performance features among five commercial RT-PCR assays. A total of consecutive nasopharyngeal (NPS) samples and oropharyngeal (OP) swabs were collected from 50 COVID-19 patients to analyze sensitivity and specificity. The results showed variations in sensitivity among all the RT-PCR kits examined. The Pishtaz teb assays demonstrated the highest positive percent agreement (PPA) of 95.2% (40/42), followed by Covitech (90.5% - 38/42), DaAn Gene (83.3% - 35/42), Sansure (66.66% - 28/42), and Power check of SARS- CoV-2 panel (64.3% - 27/42). Conversely, all five molecular assays demonstrated a negative percent agreement (NPA) of 100% (8/8). These findings provide a technical baseline for assessing the performance of five distinct commercial PCR assays for detecting SARS-CoV-2. They could prove practical and useful for laboratories seeking to purchase any of these assays for further clinical validation.

Highlights

·Compared five COVID-19 RT-PCR kits approved and available by Iran Ministry of Health. ·Pishtaz teb's kit identified the highest number of positive clinical samples.

  • Severe acute respiratory syndrome coronavirus
  • In vitro diagnostics
  • Coronavirus
  • SARS-CoV-2
  • Real Time RT-PCR.
DOI
10.14302/issn.2692-1537.ijcv-23-4660 Assigned by the journal but not yet registered with Crossref, so this identifier does not resolve. Cite the article URL until registration completes.
Publication history
Submitted 5 July 2023 · accepted 9 August 2023 (35 days) · published 8 September 2023 (30 days after acceptance)
License
Creative Commons Attribution 4.0 International (CC BY 4.0), as stated in the published record. Copyright and license
Status
Published. No correction, expression of concern or retraction is on record for this article.
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Research article Pages 10-17

The Covid-19 Pandemic and the Patterns of Nature

Gregory Warr1 · Les Hatton2Corresponding  ORCID 0000-0003-2226-3453

  • 1Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425 USA.
  • 2Faculty of Science, Engineering and Computing, Kingston University, Kingston, UK

Abstract, as published 30 July 2024

This paper addresses broadly the impact that unprecedented levels of scientific discovery can have on the emergent global patterns that we observe in nature. An essentially ubiquitous pattern that is associated with large complex discrete systems is attributable to the Conservation of Hartley-Shannon Information (CoHSI). One of the manifestations of CoHSI in the realm of protein structure is a distinctive equilibrium distribution of protein lengths that is dominated by a power-law. Here we examine the manner in which the accelerated pace of novel protein discovery during the Covid-19 pandemic affected this distribution, showing that despite an initial disruption, nevertheless the equilibrium state was reestablished.

  • SARS-CoV-2
  • Conservation Principle
  • Statistical Mechanics
  • Hartley Shannon Information
  • Power-Law
  • Protein Length
Publication history
Submitted 22 May 2024 · accepted 22 June 2024 (31 days) · published 30 July 2024 (38 days after acceptance)
License
Creative Commons Attribution 4.0 International (CC BY 4.0), as stated in the published record. Copyright and license
Status
Published. No correction, expression of concern or retraction is on record for this article.
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Cited by 1 The Fine Structure of the Transcriptome: Does It Reflect the Inverse Symmetry of the Genome? (2025). 10.31083/FBL45912 Recorded via crossref.

Research article Pages 18-29

COVID-19-Induced Changes in the Fibrin Network of Pulmonary and Renal Microthrombi

Manuel Meneses-Flores1,2  ORCID 0009-0005-8983-8399 · Jose S. Lopez-Gonzalez1 · Eduardo Becerril-Vargas3  ORCID 0000-0003-1339-3942 · Saray Santos-Torres2  ORCID 0000-0002-7195-0383 · Francina Bolaños-Morales4  ORCID 0000-0001-8752-1367 · Dolores Aguilar-Cazares1  ORCID 0000-0002-7475-0969 · Cesar Luna-Rivero2Corresponding  ORCID 0009-0006-5520-1848

  • 1Department of Chronic-Degenerative Diseases. Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas. Mexico City, Mexico.
  • 2Department of Pathological Anatomy. Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas. Mexico City, Mexico.
  • 3Clinical Microbiology Lab. Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas. Mexico City, Mexico.
  • 4Department of Thoracic Surgery. Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas. Mexico City, Mexico.

Abstract, as published 25 September 2024

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes coagulation disorders that affect highly vascularized organs, such as the lungs and kidneys.

Objective

The objective of this study was to report the histopathological findings of variations in the fibrin pattern of pulmonary and renal microthrombi in patients who died from SARS-CoV-2 infection.

Methods

Minimally invasive autopsies were performed on 40 patients to collect lung (n=40) and kidney (n=16) tissue samples. Histochemical and immunohistochemical staining techniques were used for histopathological analyses. Premortem laboratory data were obtained from the patients' electronic medical records.

Results

The lung tissue showed a patchy pattern, characterized by areas of both minimal and severe damage. The most significant histopathological finding was the detection of thrombi with fibrin structures organized into discrete star-shaped units, which were more frequently observed in areas with severe lung injury than in those with minimal lung injury (p = 0.012). Star-shaped fibrin structures were also observed in the renal glomerular capillaries. Immunohistochemical staining revealed the presence of platelets and the procoagulant proteins von Willebrand factor (VWF) and Factor VIII within the star-shaped fibrin thrombi. Patients with star-shaped fibrin thrombi had higher levels of the systemic inflammatory indicators C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR).

Conclusion

Our observations suggest that the inflammatory microenvironment resulting from SARS-CoV-2 infection may contribute to the formation of star-shaped fibrin units in the pulmonary and renal microthrombi.

  • SARS-CoV-2
  • Autopsy
  • Lung
  • Kidney
  • Microthombi
  • Fibrin Network
Publication history
Submitted 31 July 2024 · accepted 31 August 2024 (31 days) · published 25 September 2024 (25 days after acceptance)
License
Creative Commons Attribution 4.0 International (CC BY 4.0), as stated in the published record. Copyright and license
Status
Published. No correction, expression of concern or retraction is on record for this article.
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Publication integrity

Retraction notice in this issue

A retraction notice is part of the published record and is listed here with the research, not separated from it. It is not research and is not presented as research.

Retraction notice Page 30

Retraction Note: Profile of Children with Covid 19 Infection in our Set Up

The Publisher of the International Journal of Coronaviruses hereby retracts this article after confirming that it was previously published by another publisher. Verification of submission and publication histories established a case of duplicate publication, which violates ethical standards of originality and research integrity.

Status of that article
Retracted  It remains publicly available and is marked as retracted, so the scholarly record stays complete and citations to it still resolve.
Grounds
Duplicate publication. Handled under the Committee on Publication Ethics (COPE) guidelines, as stated in the notice.
Issued by
Editorial Office, International Journal of Coronaviruses
DOI
10.14302/issn.2692-1537.ijcv-25-5866 Assigned by the journal but not yet registered with Crossref, so this identifier does not resolve. Use the notice URL above.
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Corrections, expressions of concern and retractions are published as separate, citable items, kept in the issue where they belong, and linked to the article they concern. The journal's wider archive contains one further integrity item, an expression of concern in Volume 4. Browse the archive.

Issue record

Identifiers, access and integrity notes

This issue contains 3 research articles and one retraction notice. Retraction notices remain in the issue and link to the affected article so the publication history stays visible.

Peer review
Single-blind (double-blind on request). Editorial policies
Publication model
Articles are published individually once accepted and collected into a numbered issue, which is why the items in this issue carry different publication dates and consecutive page ranges.
The journal so far
65 published records across 17 issues and 5 volumes. Archive
DOI status
A DOI is linked only when its Crossref registration resolves. Stored identifiers that are not currently registered remain visible as plain text and are not presented as DOI links.

Submitting to this journal

The journal publishes research on SARS-CoV-2 and other human and animal coronaviruses: virology, diagnostics, immunology, epidemiology, pathology, clinical care and public health. Read the scope before submitting — it is the first thing an editor checks.

Submit a manuscript Read the aims and scope
Journal homeScope, board and recent research ArchiveAll 5 volumes and 17 issues Editorial boardMembers, affiliations and ORCID iDs About the journalWhat it publishes and how it works Aims and scopeWhat is and is not in scope Editorial policiesPeer review, ethics and corrections Instructions for authorsPreparing a manuscript Article processing chargesWhat publication costs Copyright and licenseCC BY 4.0 terms Current issueVolume 5, Issue 1

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