Dr. G. Hossein Ashrafi
Address:
School of Life Sciences, Pharmacy and Chemistry,
Kingston University London, London KT1 2EE, UK
Research Interests:
- Human Papillomavirus (HPV) Oncogenesis
- Breast Cancer Etiology and Pathology
- Viral Immune Evasion (HPV E5 Protein)
- Molecular and Cell Biology of Cancer
- Transcriptomics and Gene Expression Analysis
- Cervical and Anogenital Cancer
- Diagnostics and Global Cancer Prevention
Biography:
Dr. G. Hossein Ashrafi is a highly experienced researcher and lecturer specializing in Pathology, Cancer Biology, and Molecular Virology. His principal research area is the study of Human Papillomavirus (HPV) oncogenesis, with a specific focus on the virus’s molecular mechanisms in non-cervical malignancies, particularly Breast Cancer and anogenital tumors. Dr. Ashrafi's work explores how HPV oncoproteins, such as E5, E6, and E7, modulate host cell pathways and facilitate immune evasion. His current research utilizes transcriptomic analysis and molecular techniques to elucidate the controversial association between high-risk HPV and cancer development.
Education Details
- Ph.D: Beatson Institute for Cancer Research, University of Glasgow
- FIBMS (Fellow of the Institute of Biomedical Science)
- FHEA (Fellow of the Higher Education Academy)
Professional Background
- Faculty Member (Current), School of Life Sciences, Pharmacy and Chemistry, Kingston University London, UK.
- Expertise (Current): Pathology and Cancer Biology.
- Previous/Concurrent Researcher at institutions including the University of Glasgow, UK.
Achievements
- Internationally recognized expert in the molecular pathology of Human Papillomavirus (HPV) infections and cancer etiology.
- Key publications focusing on the viral oncoprotein E5 and its role in downregulating host immune responses (e.g., HLA Class I).
- Extensive research collaboration network addressing the prevalence of HPV in diverse cancer types (breast, prostate, oesophageal, bladder).
Current Research Projects
Dr. Ashrafi's current research utilizes molecular and genetic techniques to explore viral and host interactions:
- Transcriptomic analysis of HPV-positive tissues (e.g., oesophageal) to identify gene expression changes that precede malignancy.
- Investigating the correlation and mechanisms through which HPV contributes to the etiology of breast and prostate cancer.
- Assessing the regulatory effects of natural products (e.g., Ficus carica latex) on cell cycle progression in HPV-positive cancer cell lines.
Academic Profiles of Dr. G. Hossein Ashrafi
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Publications:
Dr. Ashrafi maintains a prolific publication record focusing on the translational research of advanced nanomaterials for environmental and engineering applications.
- Ashrafi, G. H., Ozdogan, M., & Cakir, M. O. (2025). Papillomavirus-Induced Oncogenesis: Bridging Molecular Mechanisms, Diagnostics, and Global Prevention Strategies. Viruses, 17(4), 515.
- Ozdogan, R., Cakir, M. O., Ashrafi, G. H., & Bilge, U. (2025). Diversity of human papillomavirus-16 L1 in the Asian region: a comparative analysis of sequences. Article, 2(2), 53-63.
- Shafiq, M. O., Cakir, M. O., Bilge, U., Pasha, Y., & Ashrafi, G. H. (2024). Transcriptomic analysis of HPV-positive oesophageal tissue reveals upregulation of genes linked to cell cycle and DNA replication. International Journal of Molecular Sciences, 26(1), 56.
- Ahmed, M. Y., Cakir, M. O., Salman, N. A., Sandhu, S., & Ashrafi, G. H. (2024). Concurrent high risk HPV35, HPV45, and HPV59 infections in prostate and bladder cancer tissues of a single patient: A case report. Heliyon, 10(15), e35074.
- Cakir, M. O., Bilge, U., Ghanbari, A., & Ashrafi, H. (2023). Regulatory effect of Ficus carica latex on cell cycle progression in human papillomavirus-positive cervical cancer cell lines: insights from gene expression analysis. Pharmaceuticals, 16(12), 1723.
Last Updated on October 03, 2025