Research Topic · Peer-Reviewed

Hormone Therapy During Perimenopause

Perimenopause is a natural transition that happens to women during the aging process. It is the time when the body starts to slow down the production of estrogen and progesterone, which are essential for maintaining reproductive functions. Women usually enter perimenopause in their 40s, but it can start earlier or l…

Curated from this journal's research 📚 1 peer-reviewed article cited 🔖 ISSN 2381-862X 🗓 Reviewed July 2026

Overview

Perimenopause is a natural transition that happens to women during the aging process. It is the time when the body starts to slow down the production of estrogen and progesterone, which are essential for maintaining reproductive functions. Women usually enter perimenopause in their 40s, but it can start earlier or later than that. Hormone therapy is a treatment option that has been used to help women ease the discomfort of perimenopause. Hormones are a crucial part of female reproductive health, and their fluctuations during perimenopause can cause hot flashes, vaginal dryness, mood changes, and other symptoms. Estrogen therapy replaces the estrogen lost during perimenopause. It comes in different forms such as pills, patches, creams, and vaginal gels. Estrogen therapy can reduce the intensity and frequency of hot flashes, night sweats, and vaginal dryness. However, it is not recommended for women who had breast cancer, have a history of blood clots or stroke, or have liver disease. Progesterone therapy is also a form of hormone therapy that is used to balance the effects of estrogen in the body. Progesterone therapy comes in different forms such as pills, creams, and vaginal suppositories. It can help reduce the risk of endometrial cancer in women taking estrogen therapy. However, women who have a history of blood clots or stroke should talk to their doctors before taking progesterone therapy. Hormone therapy is not without risks, and it should be used with caution. Women who decide to use hormone therapy during perimenopause should discuss the benefits and risks with their doctors. Hormone therapy should be used for the shortest time possible and at the lowest effective dose. Regular check-ups, mammograms, and blood tests are recommended for women who take hormone therapy.

Research published in this journal

1 peer-reviewed article, ranked by relevance. Each links to its DOI.

Editorial oversight

Curated from peer-reviewed research published in Women's Reproductive Health (ISSN 2381-862X).

Journal editorial board
Paolo Ivo Cavoretto · Italy Loc Nguyen · Hong Kong Matteo Schimberni · Italy

This page summarises published research for orientation; it is not medical or professional advice.