Research Topic · Peer-Reviewed

Metastatic Thyroid Cancer

Metastatic Thyroid Cancer refers to thyroid carcinoma that has spread beyond the gland, either to regional cervical lymph nodes or to distant sites such as the lungs and bone. Its behavior, prognosis and treatment depend strongly on the underlying histotype. Differentiated thyroid cancers, including papillary and fo…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 24× across the literature 🔖 ISSN 2574-4496 🗓 Reviewed July 2026

Overview

Metastatic Thyroid Cancer refers to thyroid carcinoma that has spread beyond the gland, either to regional cervical lymph nodes or to distant sites such as the lungs and bone. Its behavior, prognosis and treatment depend strongly on the underlying histotype. Differentiated thyroid cancers, including papillary and follicular carcinoma, often retain iodine avidity even when metastatic, making them amenable to surgery followed by radioactive iodine for iodine-avid disease, an approach reflected in the listed research on differentiated tumors treated with surgery and radioiodine, alongside attention to radiation safety considerations such as household exposure after ablation. Medullary thyroid carcinoma, which arises from calcitonin-producing parafollicular cells, does not concentrate iodine, and metastatic cases driven by actionable RET mutations may respond to targeted RET inhibitors, as illustrated by reported response to pralsetinib. Anaplastic carcinoma is rare, highly aggressive and frequently presents with widespread disease. The thyroid can also be a site of metastasis from other primary tumors, and image-guided ablation offers a localized option for selected metastatic lesions. Detection relies on imaging, biochemical markers and radioiodine scanning for iodine-avid disease. Overall, treatment is tailored to histology and molecular profile, integrating surgical resection, radioactive iodine where uptake permits, molecularly targeted therapy for actionable mutations, and image-guided local techniques to control distant or recurrent disease.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2018

In The Pursuit of The Perfect Thyroid Care

Kumar Sahoo ManasCorresponding author
Consultant Nuclear Medicine & PET/CT, Department of Nuclear Medicine &PET-CT. Medanta-The Medicity, Gurugram, India.
Thyroid Cancer doi:10.14302/issn.2574-4496.jtc-18-1986
2019

Image Guided Ablations for Thyroid Tumours

Nicosia LucaCorresponding author
Division of Breast Radiology, European Institute of Oncology IRCCS, Milan, Italy, European Institute of Oncology IEO, IRCCS, Via Giuseppe Ripamonti, 435 - 20141 Milano MI, Italy
Thyroid Cancer Cited by 2 doi:10.14302/issn.2574-4496.jtc-19-2657

How this research is being cited

The 11 articles above have been cited 24 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Metastatic Thyroid Cancer, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Thyroid Cancer (ISSN 2574-4496).

Journal editorial board
Giovanni Mauri · Italy Pamela Pinzani · Italy Byeong-Cheol Ahn · South Korea

This page summarises published research for orientation; it is not medical or professional advice.