Insulin secretion is the regulated release of insulin from the beta cells of the pancreatic islets into the bloodstream, the principal mechanism by which the body lowers blood glucose. It is triggered chiefly by a rise in plasma glucose, which beta cells metabolize to raise the ATP-to-ADP ratio, closing ATP-sensitiv…
Insulin secretion is the regulated release of insulin from the beta cells of the pancreatic islets into the bloodstream, the principal mechanism by which the body lowers blood glucose. It is triggered chiefly by a rise in plasma glucose, which beta cells metabolize to raise the ATP-to-ADP ratio, closing ATP-sensitive potassium channels, depolarizing the membrane, and admitting calcium to drive exocytosis of insulin granules; the response is biphasic and modulated by incretin hormones, amino acids, fatty acids, and autonomic signals. Defective or insufficient insulin secretion, whether through beta-cell loss or dysfunction, underlies the hyperglycaemia of diabetes, and its preservation is a central therapeutic goal. The peer-reviewed work assembled here engages the metabolic and endocrine context of insulin secretion and glucose regulation: metabolomic profiling in type 2 diabetes, dietary strategies for reversing obesity, complementary therapy with glimepiride in diabetic models, surrogate indices of insulin sensitivity in obese women, cinnamon supplementation in polycystic ovary syndrome, the contribution of thyroid hormones in obesity, and the management of type 2 diabetes through plant-derived agents. Across these studies insulin secretion is situated within glucose homeostasis, diabetes pathophysiology, and the influence of diet, obesity, and endocrine factors. The collection frames insulin secretion as the beta-cell function central to glycaemic control, whose failure drives diabetes.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 62 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Insulin Secretion, linking to each citing work.