Research Topic · Peer-Reviewed

Colorectal Cancer

Colorectal cancer is a cancer that develops in the colon or rectum, the lower part of the large intestine, and ranks among the most common malignancies and causes of cancer death worldwide. The disease usually arises from precancerous polyps in the bowel lining that, over years, may acquire successive genetic and ep…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 65× across the literature 🔖 ISSN 2578-2371 🗓 Reviewed July 2026

Overview

Colorectal cancer is a cancer that develops in the colon or rectum, the lower part of the large intestine, and ranks among the most common malignancies and causes of cancer death worldwide. The disease usually arises from precancerous polyps in the bowel lining that, over years, may acquire successive genetic and epigenetic changes leading to invasive cancer. Its risk is influenced by age, hereditary predisposition, chronic inflammation, and dietary and lifestyle factors, and it can spread beyond the bowel, with the liver being a frequent site of metastasis through portal venous drainage. Because precursor lesions are detectable, screening with colonoscopy and stool-based tests such as fecal immunochemical testing enables prevention and early diagnosis, while treatment of established disease combines surgery, chemotherapy, radiotherapy, and immune-based or targeted approaches according to stage. Research themes pertinent to gastrointestinal and hepatic medicine include the molecular biology of tumor progression and metastasis, screening and early detection, perioperative risk, and dietary and survivorship considerations. Studies published in this area cover colorectal cancer gene regulation, mechanisms of resistance to apoptosis, adhesion-molecule and gene-expression analyses in tumor tissue, suppression of metastasis through E-cadherin, anatomical contributors to interval cancers, screening programs, dietary intervention, perioperative cardiac risk, and the psychological dimensions of survivorship.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2016

GR-RNF43 Regulation in Colorectal Cancer

Chan ChristinaCorresponding author
Cell and Molecular Biology Program, Michigan State University, 567 Wilson Road, Rm 2240A, East Lansing, Michigan 48824, USA
Exact topic Proteomics and Genomics Research Cited by 1 doi:10.14302/issn.2326-0793.jpgr-16-941

How this research is being cited

The 12 articles above have been cited 65 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Colorectal Cancer, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Spleen And Liver Research (ISSN 2578-2371).

Journal editorial board
Florin Graur · Romania

This page summarises published research for orientation; it is not medical or professional advice.