Adverse reactions are harmful or unintended responses to medical interventions, encompassing adverse drug reactions to medicines, reactions to vaccines, and hypersensitivity to therapeutic agents. Adverse drug reactions are conventionally distinguished into type A, dose-dependent and predictable extensions of a drug…
Adverse reactions are harmful or unintended responses to medical interventions, encompassing adverse drug reactions to medicines, reactions to vaccines, and hypersensitivity to therapeutic agents. Adverse drug reactions are conventionally distinguished into type A, dose-dependent and predictable extensions of a drug's pharmacology, and type B, idiosyncratic and immune-mediated, with severity ranging from mild and self-limiting to serious and life-threatening. They arise through pharmacological, toxic, allergic, and idiosyncratic mechanisms, are influenced by dose, drug interactions, and patient factors, and impose clinical and economic burdens that make pharmacovigilance and causality assessment essential. Vaccine reactions, though generally mild and local, are similarly monitored for rare serious events. The peer-reviewed work assembled here engages these themes: adverse-drug-reaction patterns and their direct costs in patients on antiretroviral therapy, toxicity of iodinated radiographic contrast agents, characterization of a vaccine and broader vaccine-hesitancy considerations, cross-reactivity between cyclo-oxygenase inhibitors in patients hypersensitive to NSAIDs, drug-induced fever and pulmonary embolism as adverse events, and reviews of toxicology and drug-safety issues. Across these studies adverse reactions appear through drug- and contrast-induced toxicity, immunological cross-reactivity, vaccine safety, and the costs and management of adverse events. The collection situates adverse reactions as a central concern of clinical pharmacology and patient safety, spanning their mechanisms, risk factors, detection, and prevention across drug and vaccine exposures.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 35 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Adverse Reactions, linking to each citing work.