Research Topic · Peer-Reviewed

Sepsis

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Rather than the infection alone, it is the maladaptive systemic reaction, with widespread endothelial activation, microvascular and coagulation derangement, and mismatched oxygen delivery, that injures tissues distant f…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 26× across the literature 🔖 ISSN 2642-9241 🗓 Reviewed October 2026

Overview

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Rather than the infection alone, it is the maladaptive systemic reaction, with widespread endothelial activation, microvascular and coagulation derangement, and mismatched oxygen delivery, that injures tissues distant from the original focus and can progress to septic shock with refractory hypotension and elevated lactate. Clinically it is recognized through organ-dysfunction scoring and supported by markers of inflammation and perfusion, and outcomes hinge on early source control, timely antimicrobial therapy and haemodynamic resuscitation. Survivors frequently face prolonged critical-illness sequelae requiring rehabilitation. Work in this area covers rehabilitation of sepsis patients in intensive care, rapid myocardial calcification as a sequela of severe sepsis, restriction of antimicrobial usage in a neonatal unit, the use of alveolar-arterial oxygen gradients and severity scoring in pneumonia and COVID-19 cohorts, and experimental systemic inflammatory response syndrome modelled by cecal slurry with LPS and Escherichia coli to study inflammatory cytokines. Related haematological derangements, including von Willebrand factor and ADAMTS13 abnormalities and disturbances in dengue haemorrhagic fever, situate sepsis within broader inflammatory and coagulation pathophysiology. The journal publishes peer-reviewed clinical and experimental research relevant to sepsis, critical illness and systemic inflammation.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Sepsis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Respiratory Diseases (ISSN 2642-9241).

Journal editorial board
Mustafa Gul · Turkey Sasho Stoleski · North Macedonia Jason Akulian · United States

This page summarises published research for orientation; it is not medical or professional advice.