Cervical Cancer treatment comprises the therapeutic strategies used to manage malignancy of the uterine cervix, selected according to the stage and extent of disease, tumour characteristics, and the patient's circumstances. For localised disease, surgery to remove the tumour and surrounding tissue is a principal opt…
Cervical Cancer treatment comprises the therapeutic strategies used to manage malignancy of the uterine cervix, selected according to the stage and extent of disease, tumour characteristics, and the patient's circumstances. For localised disease, surgery to remove the tumour and surrounding tissue is a principal option, while radiotherapy, including external-beam radiation and brachytherapy in which radioactive sources are placed within or adjacent to the tumour, is central to the treatment of locally advanced disease; comparative work has assessed two-dimensional against three-dimensional brachytherapy planning to improve outcomes. Concurrent chemotherapy is frequently combined with radiation, and systemic and molecularly targeted approaches are of growing interest, informed by studies of activated signalling pathways such as PI3K/mTOR/AKT in cervical tumours. Because most cervical cancers are driven by persistent infection with high-risk human papillomavirus, prevention and early detection through screening are integral to reducing the burden of disease that ultimately requires treatment, and uptake of screening is examined across diverse populations. Significance lies in the high curability of disease detected early and the importance of stage-appropriate, multimodal management. Principal sub-areas include surgical management, radiotherapy and brachytherapy, concurrent chemoradiation, targeted and emerging systemic therapies, and the screening and HPV-related context that shapes prevention and timely intervention.
7 peer-reviewed articles, ranked by relevance. Each links to its DOI.