All Articles

Rearing Density Impacts Juvenile Bluegill Lepomis macrochirus Growth in a Recirculating Aquaculture System

Abstract:

The effects of rearing density on large juvenile bluegill Lepomis macrochirus growth in recirculating aquaculture systems are relatively unknown. This 63-day study evaluated three initial densities: low (6 kg/m³), intermediate (12 kg/m³), and high (18 kg/m³). Final densities were low (8.1 kg/m³), intermediate (16.6 kg/m³), and high (20.9 kg/m³). At the end of the study, fish reared in the low-density tanks had a mean (SD) weight of 95.99 (7.49) g, which was significantly heavier than the 75.70 (4.28) g mean weight of fish in the high-density tanks. At 86.23 (7.63) g, the weight of individual fish in the intermediate-density treatment was not significantly different from either the low or high-density treatments. Specific growth rate was also significantly greater in the low-density treatment than in the high-density treatment. Individual fish total lengths were not significantly dif...

USE OF STEM CELL GROWTH AND DIFFERENTIATION FACTORS (SCDSF) IN CENTRAL VERTIGO

Abstract:

The clinical use of SCDSF factors in neuro-degenerative pathologies offers a potential therapeutic opportunity. Our observational study aims to evaluate its efficacy in patients affected by Central Vertigo1.

A case series divided into two subgroups, all affected by non-migrainous central vertigo, was selectively subjected, in epigenetic terms versus the genome, to the administration of SCDSF with a regenerative action or to the administration of a reprogramming and then regenerative action. The cohort was divided into two groups due to the emergence of a resistance to the action of neuro-regenerative SCDSF when administered individually according to consolidated therapy schemes. To recover efficacy, it became necessary to first administer reprogramming SCDSF and only subsequently the neuro-regenerative SCDSF.

The observation that a therapeutic barrier was overcome during the study—a barrier ...

Discovery of A New Species of Sap Sucking Plant Mite (Acari: Eriophyoidea) Infesting Medicinal Plant From Sub Himalayan Region of India

Abstract:

During general surveys of eriophyoid mites in the Sub-Himalayan region of India, a new species, Diptilomiopus subhimalayansis n. sp. (family Diptilomiopidae), was discovered on the abaxial (undersurface) leaves of Holarrhena pubescens Wall. ex G.Don (Apocynaceae). Because this species is new to science, its morphometric and diagnostic features are fully described and illustrated herein. A brief discussion on the genus Diptilomiopus and the taxonomic relationships of this new species with other related eriophyoid mites are also provided. This new mite species damages its economically important host plant through sap-sucking activity, which causes leaf rusting and brown patches as visible symptoms. This infestation renders the leaves unsuitable for medicinal use. Consequently, taxonomic studies of this pest and a clear understanding of its host plant interactions are essential for developing effective control strate...

Spatial misalignment of micro-environmental hazards: how containers drive mosquito risk in New Orleans

Abstract:

Mosquito-borne risk in Gulf Coast cities is often attributed to broad environmental pressures, yet the extent to which parcel-level conditions drive standing water and larval habitats remains uncertain. This study analyzes environmental predictors of mosquito-relevant indicators across New Orleans using municipal inspection data from 951 residential parcels linked with district-level sociodemographic characteristics. Results show that while standing water was detected on 7.3% of parcels, larval habitats were rare (<1%), a pattern consistent with ecological expectations that only a small subset of water-holding sites support active mosquito development. Even with this low event frequency, container presence emerged as the dominant predictor of both outcomes, strongly associated with standing water (p < .001) and larval habitats (p < .05). Yard condition, property condition and water-feature maintenance showed no independent associations. M...

Frond emission from pinnae tips in Nephrolepis cordifolia

Abstract:

The emission of completely developed secondary fronds from pinnae tips is described for the first time in a fern belonging to the species Nephrolepis cordifolia. The phenotype described in the paper has so far been reported very rarely and only in other Nephrolepisspecies. The phenotype demonstrates that the development of a whole frond from the apex of a secondary leaf is possible and it can be related to an alteration in the meristematic activity of the pinna apex. The stability of the phenotype over time, the occurrence of all the developmental stages of the phenotype in the same frond and the recurring appearance of the phenomenon in plants propagated from the original individual make the germplasm described in this work a plant model suitable for investigating leaf morphological plasticity in plants.

Advancements in Cancer Gene Therapy: A Comprehensive Review

Abstract:

Gene therapy is a cancer treatment that is superior to chemotherapy, radiotherapy, and other less selective and specifically harmful forms of treatment. It entails the aberrant replacement, alteration, and deletion of a gene within a normal or healthy copy of a gene. Recent trials have made significant progress toward improved targeting and expression in particular tumors, shielding patients from several challenges, such as biosafety, low-specificity, and low-efficiency delivery. To replicate transgenes and vectors more safely and effectively, numerous genetic approaches are being improved. These developments in gene treatments include the ability to be modified for recurring cancer treatment, with the potential to elevate neoplastic disorders as the main therapeutic target. This review discusses the developments in cancer gene therapy and how they affect individuals undergoing gene transfer via different methods.

The Advantages of Employing the Immune Response Mediated by Immunoglobulins in Preclinical and Clinical Research: An Essential Review

Abstract:

Immunoglobulins, commonly known as antibodies, are glycoprotein molecules present on B lymphocytes and within the bloodstream. They are essential components of the immune response, as they detect the harmful molecules of test compounds and stimulate the immune system to manifest proportional counter-responses. This means that when the body encounters harmful molecules and pathogens, B cells must respond to every harmful antigen by producing antibodies tailored to bind to those antigens. This process is enhanced through class switching, which allows B cells to change the type of antibody they produce, and somatic hyper-mutation, which increases the binding affinity of antibodies by introducing mutations in the antibody genes. These mechanisms ensure an effective and precise immune response, enabling the body to defend itself efficiently against a wide range of harmful antigens and adapt its response to future infections or chemical expo...

Assessing the Effects of Blessing (Biofield) Energy Treatment on Zea mays L. saccharata Productivity

Abstract:

Sweet corn (Zea mays L. saccharata) is a high-demand, nutrient-sensitive cereal crops whose yield and crop quality depend heavily on early vegetative vigor and stress resilience. Spiritual Blessing (Biofield) Energy Treatment (SBET) has emerged as a non-invasive, biostimulatory approach to alter seed germinability, metabolic efficiency, and physiological development without ecological toxicity.

Use of a Novel Exogenous Allogeneic Multi-Growth Factor Concentrate in Bone Regeneration of the Mandible: A Case Report

Abstract:

Regeneration of new bone continues to be one of the most significant challenges in implant dentistry to correct osseous deficiencies in preparation for dental implant surgery. The need for effective bone regenerative strategies has fueled the development of many therapeutic methods, including the use of biologics such as bone morphogenetic proteins, bone marrow aspirates, mesenchymal stem cells, and platelet-derived growth factors. One therapeutic strategy that has not been investigated is the use of exogenous growth factors on bone regeneration of the jaws. The goal of this study is to evaluate if a novel exogenous allogeneic multi-growth factor concentrate, AlloSpark-GF has a positive effect on bone regeneration in the grafted mandible using histology and histomorphometry.

An Integrated Systems Thinking-Artificial Intelligence Approach to Advancing Biology and Biomedicine

Abstract:

The complexity of living systems, ranging from cellular networks to organisms to ecosystems, poses a significant challenge to the progress of contemporary biology and biomedicine. Living organisms are complex adaptive systems that are characterized by nonlinear interactions, causal-dynamic feedback loops, and context-dependent behaviors that give rise to emergent properties that are not completely explainable or predictable from the properties of the individual components alone. Investigating and understanding systemic complexity is therefore essential for advancing biology and biomedicine. Recently, artificial intelligence (AI) has been developed for analyzing large-scale, high-dimensional datasets generated by experimental and clinical research. AI enables the identification of correlations, causal patterns, and predictive relationships, which are difficult to discern using traditional analytical approaches. However, without an overarching framework, it risks be...